We are glad to present a brief report on the progress of Precision Cancer Medicine (PCM) in 2021. Some of the highlights include:

- PCM has an internationalized multidisciplinary editorial board of 253 members from 22 countries.
- PCM has 40 articles published in 2021 and has 9 special series exploring trending topics (1 completed and 8 ongoing).
- Website pageviews almost doubled the number every year from 2018 to 2021, reaching 80,678 in 2021 and the number of website users has also increased remarkably, reaching 25, 710 in 2021 according to data of Google Analytics.

We are grateful to all the editorial board members, guest editors, authors, reviewers and readers who have contributed to the steady growth of the journal in 2021 and look forward to the joint efforts and support from colleagues of all disciplines in the new year to promote research and knowledge in precision cancer medicine.