Name:Guoxiang Cai
Title: Professor of Department of Colorecal Surgery,Vice Director of Department of Surgery

Education & Professional Experience  

2001-2006——Shanghai Medical College, Fudan University, Shanghai, China
Ph.D. in Oncology
1996-2001——Shanghai Medical College, Fudan University, Shanghai, China
B.S. in Clinical Medicine and B.A. in Hygiene Management

Professional EXPERIENCES
2017.07——to present Vice Director of the Department of Surgery
Fudan University Shanghai Cancer Center, Shanghai, China
2016.12-2017.06——Chief physician, Department of Colorectal Surgery
Fudan University Shanghai Cancer Center, Shanghai, China
2011.06-2016.11——Associate chief physician, Department of Colorectal Surgery
Fudan University Shanghai Cancer Center, Shanghai, China
2010.05-2011.05——Research fellow, Department of Surgery,
Sidney Kimmel Comprehensive Cancer Center 
Johns Hopkins Hospital
2007.06-2010.04——Fellow, Department of Colorectal Surgery
Fudan University Shanghai Cancer Center, Shanghai, China
2006.08-2007.05——Resident, Department of Surgery
Fudan University Shanghai Cancer Center, Shanghai, China


surgical treatment and multidisciplinary treatment of colorectal cancer


translational research of early detection, prognostic prediction, surgical treatment/multidisciplinary treatment of colorectal cancer as well as mechanism of colorectal cancer metastasis.


1.Shaobo Mo1,2†, Hui Wang3†, Lingyu Han1,2†, Wenqiang Xiang1,2, Weixing Dai1,2,Pengfei Zhao3, Fengchun Pei3, Zhixi Su3, Chengcheng Ma3, Qi Li4, Zhimin Wang5,Sanjun Cai1,2,6*, Hao Wang7*, Rui Liu3* and Guoxiang Cai1,2*.Fecal Multidimensional Assay for Non-Invasive Detection of Colorectal Cancer: Fecal Immunochemical Test, Stool DNA Mutation, Methylation, and Intestinal Bacteria Analysis.Front Oncol, 2021,11:643136(Corresponding author)

2.Li Q, Mo S, Dai W, Li Y, Xu Y, Li X, Cai G, Cai S. Changes in Incidence and Survival by Decade of Patients With Primary Colorectal Lymphoma: A SEER Analysis. Front Public Health. 2020 Oct 16;8:486401.(Co-Corresponding author)

3.Hematopoietic Gene Expression Regulation Through m6A Methylation Predicts Prognosis in Stage III Colorectal Cancer.Zhou Z, Mo S, Gu R, Dai W, Zou X, Han L, Zhang L, Wang R, Cai G.Front Oncol. 2020 Sep 30;10:572708. doi: 10.3389/fonc.2020.572708. eCollection 2020. (Corresponding author)

4.Li M, Sun K, Dai W, Xiang W, Zhang Z, Zhang R, Wang R, Li Q, Mo S, Han L, Tong T, Liu Z, Tian J, Cai G. Preoperative prediction of peritoneal metastasis in colorectal cancer using a clinical-radiomics model. Eur J Radiol. 2020 Oct 5;132:109326. (Corresponding author)

5.Sheng Zhang#, Cheng Kong#, Yongzhi Yang, Sanjun Cai, Xinxiang Li*, Guoxiang Cai* and Yanlei Ma1,2*.Human oral microbiome dysbiosis as a novel non-invasive biomarker in detection of colorectal cancer. Theranostics 2020, 10(25): 11595-1606. (Co-corresponding author)

6.Dai W, Xu Y, Mo S, Li Q, Yu J, Wang R, Ma Y, Ni Y, Xiang W, Han L, Zhang L, Cai S, Qin J, Chen WL, Jia W, Cai G.GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies.Signal Transduct Target Ther. 2020 Sep 2;5(1):177. (Corresponding author)

7.Li H, Dai W, Xia X, Wang R, Zhao J, Han L, Mo S, Xiang W, Du L, Zhu G, Xie J, Yu J, Liu N, Huang M, Zhu J, Cai G. Modeling tumor development and metastasis using paired organoids derived from patients with colorectal cancer liver metastases. J Hematol Oncol. 2020 Sep 3;13(1):119. (Corresponding author)

8.Zhenyu Liu, Xiaochun Meng, Hongmei Zhang, Zhenhui Li, Jiangang Liu, Kai Sun, Yankai Meng, Weixing Dai, Peiyi Xie, Yingying Ding, Meiyun Wang, Guoxiang Cai*, Jie Tian. Predicting distant metastasis and chemotherapy benefit in locally advanced rectal cancer. Nature Communications.2020; 11:4308. (Corresponding author)

9.Weixing Dai, Shaobo Mo, Lingyu Han, Wenqiang Xiang, Menglei Li, Renjie Wang, Tong Tong, Guoxiang Cai.Prognostic and predictive value of radiomics signatures in stage I‐III colon cancer.Clin Transl Med. 2020 Jan-Dec; 10(1): 288–293. (Corresponding author)

10.Shaobo Mo, Zheng Zhou, Weixing Dai, Wenqiang Xiang, Lingyu Han, Long Zhang, Renjie Wang, Sanjun Cai, Qingguo Li, Guoxiang Cai. Development and external validation of a predictive scoring system associated with metastasis of T1‐2 colorectal tumors to lymph nodes. Clin Transl Med. 2020 Jan-Dec; 10(1): 275–287. (Corresponding author)

11.Wang R, Han L, Dai W, Mo S, Xiang W, Li Q, Xu Y, Cai G. Cause of death for elders with colorectal cancer: a real-world data analysis. J Gastrointest Oncol. 2020 Apr;11(2):269-276. (Corresponding author)

12.Han L, Dai W, Mo S, Xiang W, Li Q, Xu Y, Wang R, Cai G. Nomogram to predict the risk and survival of synchronous bone metastasis in colorectal cancer: a population-based real-world analysis. Int J Colorectal Dis. 2020 May 16. doi: 10.1007/s00384-020-03612-z. Online ahead of print. (Corresponding author)

13.Wang R, Xiang W, Xu Y, Han L, Li Q, Dai W, Cai G. Enhanced glutamine utilization mediated by SLC1A5 and GPT2 is an essential metabolic feature of colorectal signet ring cell carcinoma with therapeutic potential. Ann Transl Med. 2020 Mar;8(6):302. (Corresponding author)

14.Han L, Mo S, Xiang W, Li Q, Wang R, Xu Y, Dai W, Cai G.Comparison of four lymph node staging systems for predicting prognosis for stage IV rectum cancer. Ann Transl Med. 2020 Feb;8(4):111. doi: 10.21037/atm.2019.12.90. (Corresponding author)

15.Dai W, Mo S, Xiang W, Han L, Li Q, Wang R, Xu Y, Cai G.The Critical Role of Tumor Size in Predicting Prognosis for T1 Colon Cancer. Oncologist. 2020 Mar;25(3):244-251. (Corresponding author)

16.Ji Q, Zhou L, Sui H, Yang L, Wu X, Song Q, Jia R, Li R, Sun J, Wang Z, Liu N, Feng Y, Sun X, Cai G, Feng Y, Cai J, Cao Y, Cai G, Wang Y, Li Q. Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation.Nat Commun. 2020 Mar 5;11(1):1211.(Co-corresponding author)

17.Wang R, Mo S, Liu Q, Zhang W, Zhang Z, He Y, Cai G, Li X. The safety and effectiveness of carbon nanoparticles suspension in tracking lymph node metastases of colorectal cancer: a prospective randomized controlled trial. Jpn J Clin Oncol. 2020 Feb 21:hyaa011. (Co-corresponding author)

18.Gong Q, Song C, Wang X, Wang R, Cai G, Liang X, Liu J. Hyperthermic intraperitoneal chemotherapy with recombinant mutant human TNF-α and raltitrexed in mice with colorectal-peritoneal carcinomatosis. Exp Biol Med (Maywood). 2020 Feb 10:1535370220905047. (Co-corresponding author)

19.Dai W, Meng X, Mo S, Xiang W, Xu Y, Zhang L, Wang R, Li Q, Cai G. FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer. Cell Commun Signal. 2020 Jan 9;18(1):7. (Corresponding author)

20.Han L, Mo S, Xiang W, Li Q, Wang R, Xu Y, Dai W, Cai G.Prognostic accuracy of different lymph node staging system in predicting overall survival in stage IV colon cancer.Int J Colorectal Dis. 2020 Feb;35(2):317-322. (Corresponding author)

21.Feng Y, Mo S, Dai W, Li Q, Cai G, Cai S.Increasing age-related survival gap among patients with colorectal cancer: a population-based retrospective study.Int J Clin Oncol. 2020 Jan;25(1):100-109. (Co-corresponding author)

22.Zhou Z, Mo S, Dai W, Xiang W, Han L, Li Q, Wang R, Liu L, Zhang L, Cai S, Cai G. Prognostic nomograms for predicting cause-specific survival and overall survival of stage I-III colon cancer patients: a large population-based study.Cancer Cell Int. 2019 Dec 27;19:355. (Corresponding author)

23.Mo S, Zhou Z, Ying Z, Dai W, Xiang W, Han L, Li Q, Wang R, Cai G. Epidemiology of and prognostic factors for appendiceal carcinomas: a retrospective, population-based study.Int J Colorectal Dis. 2019 Nov;34(11):1915-1924. (Corresponding author)

24.Zhou Z, Mo S, Dai W, Ying Z, Zhang L, Xiang W, Han L, Wang Z, Li Q, Wang R, Cai G.Development and Validation of an Autophagy Score Signature for the Prediction of Post-operative Survival in Colorectal Cancer.Front Oncol. 2019 Sep 9;9:878. (Corresponding author)

25.Mo S, Dai W, Xiang W, Li Y, Feng Y, Zhang L, Li Q, Cai G.Prognostic and predictive value of an autophagy-related signature for early relapse in stages I-III colon cancer.Carcinogenesis. 2019 Jul 20;40(7):861-870. (Corresponding author)

26.Dai W, Li Y, Wu Z, Feng Y, Cai S, Xu Y, Li Q, Cai G.Pathological nodal staging score for rectal cancer patients treated with radical surgery with or without neoadjuvant therapy: a postoperative decision tool.Cancer Manag Res. 2019 Jan 7;11:537-546. (Corresponding author)

27.Ji Q, Cai G, Liu X, Zhang Y, Wang Y, Zhou L, Sui H, Li Q.MALAT1 regulates the transcriptional and translational levels of proto-oncogene RUNX2 in colorectal cancer metastasis. Cell Death Dis. 2019 May 16;10(6):378. (Co-first author)

28.Li Y, Chen Y, Qiu C, Ma X, Lei K, Cai G, Liang X, Liu J. 17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.J Cell Biochem. 2018 Oct 30. doi: 10.1002/jcb.27397. [Epub ahead of print] (Corresponding author)

29.Li Q, Dai W, Jia H, Li Y, Xu Y, Li X, Cai G, Cai S. Prognostic Impact of Hypochloremia in Patients With Stage I to III Colorectal Cancer After Radical Resection. Dis Colon Rectum. 2018 Nov;61(11):1273-1280. (Co-corresponding author)

30.Dai W, Feng Y, Mo S, Xiang W, Li Q, Wang R, Xu Y, Cai G. Transcriptome profiling reveals an integrated mRNA-lncRNA signature with predictive value of early relapse in colon cancer.Carcinogenesis 2018 Oct 8;39(10):1235-1244. (Corresponding author)

31.Huan Zhang*, Weixing Dai*, Caixia Fu, Xu Yan, Alto Stemmer, Tong Tong, Guoxiang Cai.Diagnostic value of whole-body MRI with diffusion-weighted sequence for detection of peritoneal metastases in colorectal malignancy.Cancer Biol Med.2018 May;15(2):165-170. (Corresponding author)

32.Mo S, Dai W, Xiang W, Li Q, Wang R, Cai G.Predictive factors of synchronous colorectal peritoneal metastases: Development of a nomogram and study of its utilities using decision curve analysis.Int J Surg. 2018 May 3;54(Pt A):149-155. (Corresponding author)

33.Mo S, Dai W, Xiang W, Huang B, Li Y, Feng Y, Li Q, Cai G. Survival Contradiction Between Stage IIA and Stage IIIA Rectal Cancer: A Retrospective Study. Journal of cancer.2018; 9(8): 1466-1475. (Corresponding author)

34.Dai W, Li Y, Mo S, Feng Y, Zhang L, Xu Y, Li Q, Cai G.A robust gene signature for the prediction of early relapse in stage I-III colon cancer.Mol Oncol. 2018;12:463-75. (Corresponding author)

35.Xie YH, Gao QY, Cai GX, Sun XM, Zou TH, Chen HM, Yu SY, Qiu YW, Gu WQ, Chen XY, Cui Y, Sun D, Liu ZJ, Cai SJ, Xu J, Chen YX, Fang JY.Fecal Clostridium symbiosum for Noninvasive Detection of Early and Advanced Colorectal Cancer: Test and Validation Studies. EBioMedicine. 2017 Nov;25:32-40. (Co-first author)

36.Dai W, Li Y, Meng X, Cai S, Li Q, Cai G.Does tumor size have its prognostic role in colorectal cancer? Re-evaluating its value in colorectal adenocarcinoma with different macroscopic growth pattern.Int J Surg. 2017 Sep;45:105-112. (Corresponding author)

37.Qiu C, Li Y, Liang X, Qi Y, Chen Y, Meng X, Zheng H, Xu Y, Cai S, Cai G, Liu J.A study of peritoneal metastatic xenograft model of colorectal cancer in the treatment of hyperthermic intraperitoneal chemotherapy with Raltitrexed.Biomed Pharmacother. 2017 May 20;92:149-156. (Co-corresponding author)

38.Shaobo Mo and Guoxiang Cai. Multidisciplinary Treatment for Colorectal Peritoneal Metastases: Review of the Literature. Gastroenterol Res Pract. 2016;2016:1516259. (Corresponding author)

39.Huang B, Ni Mengdong, Chen Chen, Cai G, Cai S. LODDS is superior to lymph node ratio for the prognosis of node-positive rectal cancer patients treated with preoperative radiotherapy.Tumori. 2017 Jan 21;103(1):87-92. (Co-orresponding author)

40.Huang B, Feng Y, Ni M, Chen C, Cai G.Heterogeneous survival between stage IIA and stage IIIA colon cancer when different numbers of lymph nodes are harvested.ANZ J Surg.2018 Apr;88(4):316-321. (Corresponding author)

41.Huang B, Feng Y, Zhu L, Xu T, Huang L, Cai G. Smaller tumor size is associated with poor survival in stage II colon cancer: An analysis of 7,719 patients in the SEER database. Int J Surg. 2016 Sep;33 Pt A:157-63. doi: 10.1016/j.ijsu.2016.07.073. (Corresponding author)

42.Huang B, Chen C, Ni M, Mo S, Cai G, Cai S. Log odds of positive lymph nodes is a superior prognostic indicator in stage III rectal cancer patients: A retrospective analysis of 17,632 patients in the SEER database. Int J Surg. 2016 Aug;32:24-30. (Co-corresponding author)

43.Li Q, Liang X, Wang Y, Meng X, Xu Y, Cai S, Wang Z, Liu J, Cai G. miR-139-5p Inhibits the Epithelial-Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2. Sci Rep. 2016 May 31;6:27157. (Corresponding author)

44.Zou F, Mao R, Yang L, Lin S, Lei K, Zheng Y, Ding Y, Zhang P, Cai G, Liang X, Liu J. Targeted deletion of miR-139-5p activates MAPK, NF-κB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer.FEBS J. 2016 Apr;283(8):1438-52. (Co-corresponding author)


●Third Prize of Science and Technology Progress of the Chinese Preventive Medicine Association, 2019

●Second Prize of Science and Technology Progress of the Shanghai Preventive Medicine Association, 2018

●Second Prize of the Surgical Videos Competition of the Chinese Journal of Colorectal Disease (Electronic Edition), 2017

●Runner up of the Laparoscopic Operation Video Competition in Shanghai and Zhejiang Province Held by the Greater China Laparoscopic Colorectal Institute, 2017

●Second Prize of Chinese Medical Science and Technology Award, 2015

●Second Prize of Science and Technology Progress of the Ministry of Education, 2015/2013

●Second Prize of Science and Technology Progress of Shanghai, 2013

Out-patient Schedule   Monday Morning, Tuesday Morning and Afternoon