Department: Cancer Institute
Title: M.D., Professor

Education & Professional Experience  

Dr. Da-Qiang Li, M.D., now is a full professor of Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University. He received M.D. degree from Chongqing Medical University (Chongqing, China) in 2003, and then completed his postdoctoral training at Fudan University, Case Western Reserve University (Cleveland, OH), University of Texas M.D. Anderson Cancer Center (Houston, TX) and George Washington University (Washington, DC). In November 2009, he was appointed as a Faculty and an Assistant Research Professor at Department of Biochemistry and Molecular Medicine, George Washington University, and then promoted to an Associate Research Professor position in July, 2013 at the same institute. In September, 2013, he joined in Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University as a full professor and Principle Investigator. His research projects mainly focus on understanding the molecular mechanism of tumor invasion and metastasis and therapeutic resistance. To date, he has published over 35 SCI papers including Cancer Cell, Mol Cell, Cell Rep, Nat Commun, PNAS, J Cell Biol and Hepatology. Currently he is an editorial board member for 6 international journals including Cancer Research and is a peer reviewer for 16 international journals.


Molecular mechanisms of tumor metastasis and therapeutic resistance

Research   Although advances have been made in tumor diagnosis and therapies, most cancer-related deaths still result from tumor invasion and metastasis. An appreciation of the molecular mechanisms to control the invasive and metastatic behavior of cancer cells may likewise lead to better methods to control their growth and spread within host tissues. Another leading cause of cancer-related death is increased chemo-resistance and radio-resistance of cancer cells. It is increasingly recognized the importance of DNA repair in cancer therapeutic resistance. Thus, my research projects primarily involve those two related areas, including understanding of the molecular mechanism of tumor invasion and metastasis and targeting DNA repair pathways to reduce cancer therapeutic resistance.

1.*Li DQ, *Pakala SB, Reddy SD, Peng S, Balasenthil1 S, Lee CC, Rea MA, Kumar R. Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun, 2013; 4: 2545 (*Contributed equally)

2.*Li DQ, Nair SS, Ohshiro K, Kumar A, Nair VS, Pakala SB, Reddy SD, Gajula RP, Eswaran J, Aravind L, *Kumar R. MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response. Cell Rep, 2012; 2: 1657–1669 (*Co-corresponding authors)

3.Li DQ, Pakala SB, Reddy SD, Ohshiro K, Zhang JX, Wang L, Zhang Y, de Alborán IM, Pillai MR, Eswaran J, Kumar R. Bidirectional autoregulatory mechanism of metastasis  associated protein 1-alternative reading frame pathway in oncogenesis. Proc Natl Acad Sci U S A, 2011; 108: 8791-8796

4.Li DQ, Ohshiro K, Reddy SD, Pakala SB, Lee MH, Zhang Y, Rayala SK, Kumar R. E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. Proc Natl Acad Sci U S A, 2009; 106: 17493-17498

5.*Zhang JX, *Li DQ, He AR, Motwani M, Vasiliou V, Eswaran J, Mishra L, Kumar R. Synergistic inhibition of hepatocellular carcinoma growth by cotargeting chromatin modifying enzymes and poly (ADP-ribose) polymerases. Hepatology, 2012; 55: 1840-1851 (*Contributed equally)

6.*Molli PR, *Li DQ, Bagheri-Yarmand R, Pakala SB, Katayama H, Sen S, Iyer J, Chernoff J, Tsai MY, Nair SS, Kumar R. Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol, 2010; 190: 101-114 (Comment in Nat Rev Mol Cell Biol, 2010; 11: 542) (*Contributed equally)

7.Miao H, Li DQ, Mukherjee A, Guo H, Petty A, Cutter J, Basilion JP, Sedor J, Wu J, Danielpour D, Sloan AE, Cohen ML, Wang B. EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell, 2009; 16: 9-20 (Featured in Nature, 2009; 461:149 under Research Highlights)

8.Nair SS, Li DQ, Kumar R. A core chromatin remodeling factor instructs global chromatin signaling through multivalent reading of nucleosome codes. Mol Cell, 2013; 49: 704–718


2013 Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning