Name: Hu Xin
Department: Cancer Institute
Title:Associate Professor

Education & Professional Experience     Dr. Hu received his bachelor degree in Foundational Medical Science in Fudan University in 2003.  He received his Ph.D. degree of molecular oncology at State key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Fudan University in 2008. And he also has two years pharmaceutical industry experience in Shangpharma and three postdoctoral training experiences in MD. Cancer Center (Houston, TX) during 2008-2012. In April 2012, he joined in Fudan University Shanghai Cancer Center as an associate professor and junior Principle Investigator at Cancer Institute.
Specialty   Breast cancer, Cancer Genetics
Research   Dr. Hu is majorly investigating how the BRCA1 associated complexes are involved in breast cancer. He is also working for the DNA damage repair mechanism and library screening. His works have been published in Hepatology, Cancer Research, Journal of Biological Chemistry, Oncotarget, International Journal of Cancer and other journals.

Selected papers
1.Ye FG#, Song CG#,*, Cao ZG, Xia C, Chen DN, Chen L, Li S, Qiao F, Ling H, Yao L, Hu X*, Shao ZM. Cytidine deaminase axis modulated by miR-484 differentially regulates cell proliferation and chemoresistance in breast cancer. Cancer Res 2015 Feb 2. pii: canres.2341.2014. Co-corresponding author IF= 9.28

2.He M, Hu X*, Chen L, Cao AY, Yu KD, Shi TY, Kuang XY, Shi WB, Ling H, Li S, Qiao F, Yao L, Wei QY, Di GH, Shao ZM* A recessive variant of XRCC4 predisposes to non-BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization OncoTarget. 2014 Dec 15;5(23):12218-32. Co-corresponding author IF= 6.63

3.Zheng YZ#, Cao ZG#, Hu X*, Shao ZM*. The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancer. Breast Cancer Research and Treatment. 2014 Jun;145(2):349-58.Co-corresponding author IF= 4.47

4.Wang L#, Yao L#, Zheng YZ, Xu Q, Liu XP, Hu X*, Wang P*, Shao ZM*.Expression of autophagy-related proteins ATG5 and FIP200 predicts favorable disease-free survival in patients with breast cancer. Biochem Biophys Res Commun. 2015 Feb 14. pii: S0006-291X(15)00255-7. Co-corresponding author IF = 2.28

5.Li K#, Yao L#, Chen L, Cao ZG, Yu SJ, Kuang XY, Hu X*, Shao ZM*. ID2 predicts poor prognosis in breast cancer and inhibits E-cadherin expression. OncoTargets and Therapy 2014 Jun 18;7:1083-94 Co-corresponding author IF= 2.07

6.Hu X#, Zhao Y#, He X, Li J, Wang T, Zhou W, Wan D, Wang H, Gu J*. Ciliary neurotrophic factor receptor alpha subunit-modulated multiple downstream signaling pathways in hepatic cancer cell lines and their biological implications. Hepatology 2008 Apr; 47(4):1298-308. Co-first author IF= 11.36

7.Hu X, Kim J, Castillo A, Huang M, Liu J, Wang B*. NBA1/Merit40 and BRE interaction is required for the integrity of two distinct deubiqutinating enzyme BRCC36 containing complexes. J Biol Chem. 2011 Apr 1;286(13):11734-45.; First author IF=4.77

8.Hu X, Paul A, Wang B. Rap80 Protein Recruitment to DNA Double-strand Breaks Requires Binding to Both Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Conjugates. J Biol Chem. 2012 Jul 20; 287(30):25510-9;
9.First author IF= 4.77

10.Peng WT#, Hu X#, Yao L#, Jiang YZ, Shao ZM*. Elevated expression of Girdin in the nucleus indicates worse prognosis for patients with estrogen receptor-positive breast cancer. Annals of Surgical Oncology. 2014 May 3. Co-first author IF= 4.12

11.Yao L#, Li K#, Peng W, Lin Q, Li S, Hu X#, Zheng X, Shao ZM* An aberrant spliced transcript of focal adhesion kinase is exclusively expressed in human breast cancer. J Transl Med. 2014 May 21;12:136. Co-first author IF= 3.99

12.Ling H#, Hu X#, Xu XL#, Liu ZB, Shao ZM*. Patients with nipple-areola Paget's disease and underlying invasive breast carcinoma have very poor survival: a matched cohort study. PLoS One. 2013 Apr 19;8(4):e61455. Co-first author IF= 3.73

13.Shi WB#, Yang LJ#, Hu X#, Zhou J, Zhang Q, Shao ZM* Clinico-pathological features and prognosis of invasive micropapillary carcinoma compared to invasive ductal carcinoma: a population-based study from china. PLoS One. 2014 Jun 30;9(6):e101390. Co-first author IF= 3.73

Ma FJ#, Liu ZB#, Hu X#, Ling H, Li S, Wu J, Shao ZM* Prognostic correlation of myeloid differentiation primary response 88 and Toll-like receptor 4 in breast cancer patients. PLoS One. 2014 Oct 31;9(10):e111639. Co-first author IF= 3.53

Awards   Award in Genetics, Dodie P. Hawn Fellowship, by MD Anderson Cancer Center 2011
Recommendation of study about NBA1/Merit40 and BRE interaction is required for the integrity of two distinct deubiqutinating enzyme BRCC36 containing complexes, by Faculty of 1000 (F1000) 2011
Out-patient Schedule